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FLASH GENE
Symbol THRA contributors: mct - updated : 03-06-2020
HGNC name thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)
HGNC id 11796
Location 17q21.1      Physical location : 38.218.445 - 38.250.118
Synonym name
  • thyroid hormone receptor, alpha (oncogene ERBA1)
  • avian erythroblastic leukemia viral (v-erb-a) oncogene homolog
  • ERBA-related 7
  • triiodothyronine receptor
  • Synonym symbol(s) ERBA1, NR1A1, THRA1, THRA2, THRA3, AR7, EAR-7.1, EAR-7.2, EAR7, ERB-T-1, ERBA-ALPHA, ERBA, MGC000261, ERB-T-1, MGC43240, RHTA
    DNA
    TYPE functioning gene
    SPECIAL FEATURE opposite orientation
    text encoding NR1D1 (alpha transcript) on the opposite orientation strand (see symbol)
    STRUCTURE 31.67 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2405 46.8 410 - 2009 19628582
    hormone binding receptor
    10 splicing 2474 54.8 490 - 2009 19628582
    not binding hormone but inhibiting THR transactivation
    10 splicing 2449 50.7 451 - 2009 19628582
    10 - 2547 54.8 490 - 2009 19628582
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly
    Reproductivemale systemprostate  highly
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text in embryonic postmitotic neurons
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal modulator domain,
  • a central bipartite (class II) zinc finger DNA binding domain
  • a C terminal ligand domain
  • HOMOLOGY
    Homologene
    FAMILY
  • steroid/thyroid hormone receptor superfamily
  • nuclear hormone receptor family
  • CATEGORY transcription factor , signaling hormone , receptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    text shuttles rapidly between the nucleus and cytoplasm (
    basic FUNCTION
  • nuclear hormone receptor for triiodothyronine mediating the biological activities of thyroid hormone
  • exhibits a dual role as an activator or repressor of its target genes in response to thyroid hormone (T(3)(
  • apparently plays an essential role in restoring the expression of the TH-regulated genes potentially involved in striatal synaptic plasticity (
  • has the capacity to play an important role in virtually all developing and adult neurons
  • is required for normal neural progenitor cell proliferation in human cerebral cortical development
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    thyroid
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • directly interacts with calreticulin (THRA can follows a cooperative export pathway in which both calreticulin and CRM1 play a role in facilitating efficient translocation of THRA from the nucleus to cytoplasm) (
  • thyroid hormone (TH), a regulator of hepatic gluconeogenesis acts through its nuclear receptor (THRA, THRB) to induce the expression of PCK1 and G6PC
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    dysregulated in breast cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    neurosensorialvisual 
    inhibition of THRA, THRB locally in the retina is a therapeutic strategy for retinal degeneration
    ANIMAL & CELL MODELS
    thyroid receptor knock-out mouse models displaying severe neurological dysfunction