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FLASH GENE

Symbol

TRD@

contributors: mct - updated : 23-05-2012

HGNC name	T cell receptor delta locus
HGNC id	12252

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a large N-terminal extracellular segment folded into two Ig-like domains with both ends joined together by a disulfide bond, one variable forming the antigen-binding site with the cognate gamma chain, one constant
	a transmembrane segment (TM1)
	a short cytoplasmic tail

conjugated

GlycoP

HOMOLOGY

Homologene

FAMILY

CATEGORY

receptor membrane

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION

encoding the T cell receptor, delta repertoire

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense

text	cellular immunity

PATHWAY

metabolism

signaling

a component

component, with the gamma chain, of the T cell receptor, associated with the CD3 complex

INTERACTION

DNA

RNA

small molecule	other,
	fragmented antigen binding, MHC restricted

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   translocation     and fusion with HOX11 in acute lymphoblastic leukemia tumoral   translocation     T-cell leukemia with t(11,14)(p13;q11) and TCRD and LMO2 genes fusion tumoral   translocation     t(5;14)(q33-34;q11) translocation constitutes a recurrent rearrangement in acute lymphoblastic leukemia, with fusion of RANBP17 and TCRD

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS