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FLASH GENE
Symbol TRD@ contributors: mct - updated : 23-05-2012
HGNC name T cell receptor delta locus
HGNC id 12252
DNA
TYPE cluster
MAPPING cloned Y linked N status confirmed
Map cen 5' - TRAV@ - TRDV2 - TRDD1 /TRDD2 -TRDD3 /TRDJ1 - TRDJ4 /TRDJ2 - TRDJ3 - TRDC - TRDV3 - TRAJ@ - TRAC - 34 - qter
Authors Lefranc IMGT (03)
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticthymus    
Digestive     
Lymphoid/Immunelymph node    
Skin/Tegument     
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneT cell
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, fetal
Text thymocyte
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a large N-terminal extracellular segment folded into two Ig-like domains with both ends joined together by a disulfide bond, one variable forming the antigen-binding site with the cognate gamma chain, one constant
  • a transmembrane segment (TM1)
  • a short cytoplasmic tail
    • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • encoding the T cell receptor, delta repertoire
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text cellular immunity
    PATHWAY
    metabolism
    signaling
    a component
  • component, with the gamma chain, of the T cell receptor, associated with the CD3 complex
    • INTERACTION
    DNA
    RNA
    small molecule other,
  • fragmented antigen binding, MHC restricted
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   translocation    
    and fusion with HOX11 in acute lymphoblastic leukemia
    tumoral   translocation    
    T-cell leukemia with t(11,14)(p13;q11) and TCRD and LMO2 genes fusion
    tumoral   translocation    
    t(5;14)(q33-34;q11) translocation constitutes a recurrent rearrangement in acute lymphoblastic leukemia, with fusion of RANBP17 and TCRD
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS