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FLASH GENE

Symbol

SORD

contributors: - updated : 18-02-2006

HGNC name	sorbitol dehydrogenase
HGNC id	11184

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	15q15      Physical location : 45.315.301 - 45.367.287
Synonym symbol(s)	SORD1
EC.number	1.1.1.14

DNA

TYPE	functioning gene
SPECIAL FEATURE
text	including two homologous genes SORD1,SORD2 resulting of a recent gene duplication event
STRUCTURE	51.00 kb     9 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       highly Reproductive male system prostate     highly Urinary kidney       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

homomer , tetramer

HOMOLOGY

Homologene

FAMILY

medium-chain dehydrogenase/reductase protein family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth

basic FUNCTION

converting sorbitol to fructose strictly using NAD(+) as coenzyme

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	binding 1 zinc ion per subunit

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS