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FLASH GENE

Symbol

SDHB

contributors: mct/npt - updated : 08-11-2016

HGNC name	succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
HGNC id	10681

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

PGL4 , CWS2 , SDHBD

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral germinal mutation       in pheochromocytoma and paraganglioma tumoral       loss of function in pheochromocytoma and paraganglioma tumoral   LOH     in pheochromocytoma with high-risk of recurrence or malignancy tumoral germinal mutation       in Cowden and Cowden-like syndromes tumoral germinal mutation       in familial renal cell carcinoma, with early onset tumoral     --low   is limited to a distinctive subset of gastric wild-type gastrointestinal stromal tumours

Susceptibility

pheochromocytoma, paraganglioma and early-onset renal cell carcinoma

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS