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FLASH GENE

Symbol

SDHB

contributors: mct/npt - updated : 08-11-2016

HGNC name	succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
HGNC id	10681

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver           stomach       highly Reproductive female system uterus cervix   highly Skin/Tegument skin       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES		globular
STRUCTURE

motifs/domains

conjugated

FlavoP

mono polymer

heteromer , dimer

HOMOLOGY

interspecies

homolog to C.elegans f42a8.2

Homologene

FAMILY

succinate dehydrogenase/fumarate reductase iron-sulfur protein family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,mitochondria,inner
	intracellular,cytoplasm,organelle,membrane

basic FUNCTION	succinate-ubiquinone oxidoreductase, catalyzing the seventh step of the citric acid cycle (tricarboxylic acid cycle)
	a crucial dosage-dependent role for SDHA, SDHB in oxygen homeostasis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

organic acid

signaling

a component

complex II of mitochondrial respiratory chain, oxidative phosphorylation, (OXPHOS)

INTERACTION

DNA

RNA

small molecule

protein	SDHA and SDHB interacted specifically with SIRT3 (SIRT3 may be an important physiological regulator of SDH activity)
	CERS5 and SDHB interaction may synergistically affect transcriptional regulation of TP53 and CDKN1A

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

PGL4 , CWS2 , SDHBD

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral germinal mutation       in pheochromocytoma and paraganglioma tumoral       loss of function in pheochromocytoma and paraganglioma tumoral   LOH     in pheochromocytoma with high-risk of recurrence or malignancy tumoral germinal mutation       in Cowden and Cowden-like syndromes tumoral germinal mutation       in familial renal cell carcinoma, with early onset tumoral     --low   is limited to a distinctive subset of gastric wild-type gastrointestinal stromal tumours

Susceptibility

pheochromocytoma, paraganglioma and early-onset renal cell carcinoma

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS