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FLASH GENE
Symbol KRT15 contributors: mct/npt - updated : 05-06-2019
HGNC name keratin 15
HGNC id 6421
PROTEIN
PHYSICAL PROPERTIES acid
STRUCTURE
motifs/domains
  • conserved central rod domain, with four helical domains (1A, 1B, 2A, 2B)
  • interrupted by non alpha helical linkers (L1, 2, 3)
  • flanked by the homology domain H1, by variable region (V1, V2) and end sequences (E1, E2)
    • mono polymer heteromer , tetramer
    HOMOLOGY
    interspecies homolog to rattus Ka15 (89.86 pc)
    homolog to murine Krt15 (89.53 pc)
    Homologene
    FAMILY
  • type I keratin family
  • intermediate filament family
    • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,intermed filament
    basic FUNCTION
  • being responsible for the structural integrity of epithelial cells
    • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    text epidermal differentiation
    PATHWAY
    metabolism
    signaling
    a component
  • heterotetramer of two type I (acidic) and two type II (neutral to basic) keratins
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • type I & II keratins
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in the Prostate carcinoma compared to the benign prostatic hyperplasia (BPH)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS