Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol KRT15 contributors: mct/npt - updated : 05-06-2019
HGNC name keratin 15
HGNC id 6421
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   predominantly
 mouthtongue  highly
Reproductivefemale systembreastmammary gland highly
 male systemprostate  highly
Respiratorylung   moderately
 respiratory tractlarynx  highly
 respiratory tracttrachea  highly
Skin/Tegumentskin   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier liningcorneal epithelium moderately
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES acid
STRUCTURE
motifs/domains
  • conserved central rod domain, with four helical domains (1A, 1B, 2A, 2B)
  • interrupted by non alpha helical linkers (L1, 2, 3)
  • flanked by the homology domain H1, by variable region (V1, V2) and end sequences (E1, E2)
    • mono polymer heteromer , tetramer
    HOMOLOGY
    interspecies homolog to rattus Ka15 (89.86 pc)
    homolog to murine Krt15 (89.53 pc)
    Homologene
    FAMILY
  • type I keratin family
  • intermediate filament family
    • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,intermed filament
    basic FUNCTION
  • being responsible for the structural integrity of epithelial cells
    • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    text epidermal differentiation
    PATHWAY
    metabolism
    signaling
    a component
  • heterotetramer of two type I (acidic) and two type II (neutral to basic) keratins
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • type I & II keratins
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in the Prostate carcinoma compared to the benign prostatic hyperplasia (BPH)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS