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FLASH GENE

Symbol

KRT15

contributors: mct/npt - updated : 05-06-2019

HGNC name	keratin 15
HGNC id	6421

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	17q21-q23      Physical location : 39.669.997 - 39.675.270
Synonym name	cytokeratin 15
	type I cytoskeletal 15
	keratin-15, basic
	keratin-15, beta
Synonym symbol(s)	K15, CK15, K1CO, KRTB

DNA

TYPE	functioning gene
STRUCTURE	5.14 kb     8 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
	Binding site   transcription factor
motif
text structure	regulators of K15 promoter activity are transcription factors C/EBP, AP-1, and NF-kappaB, nuclear receptors for thyroid hormone, retinoic acid, and glucocorticoids, and the cytokine gamma interferon IFNG (C/EBP-beta and AP-1 induced, while retinoic acid, glucocorticoid receptors, and NF-kappaB suppressed, the KRT15 promoter)

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed KRT15 8 - 1709 49.2 456 - Radoja (2004)

EXPRESSION

Type

widely

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus       predominantly   mouth tongue     highly Reproductive female system breast mammary gland   highly   male system prostate     highly Respiratory lung       moderately   respiratory tract larynx     highly   respiratory tract trachea     highly Skin/Tegument skin       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier lining corneal epithelium   moderately

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES		acid
STRUCTURE

motifs/domains	conserved central rod domain, with four helical domains (1A, 1B, 2A, 2B)
	interrupted by non alpha helical linkers (L1, 2, 3)
	flanked by the homology domain H1, by variable region (V1, V2) and end sequences (E1, E2)

mono polymer

heteromer , tetramer

HOMOLOGY

interspecies	homolog to rattus Ka15 (89.86 pc)
	homolog to murine Krt15 (89.53 pc)

Homologene

FAMILY	type I keratin family
	intermediate filament family

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,intermed filament

basic FUNCTION

being responsible for the structural integrity of epithelial cells

CELLULAR PROCESS	cell life, differentiation

PHYSIOLOGICAL PROCESS

text	epidermal differentiation

PATHWAY

metabolism

signaling

a component

heterotetramer of two type I (acidic) and two type II (neutral to basic) keratins

INTERACTION

DNA

RNA

small molecule

protein

type I & II keratins

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in the Prostate carcinoma compared to the benign prostatic hyperplasia (BPH)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS