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FLASH GENE

Symbol

APOA4

contributors: mct - updated : 17-02-2017

HGNC name	apolipoprotein A-IV
HGNC id	602

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in follicular fluid from Polycystic ovary syndrome (PCOS) patients compared with those from normal controls

Susceptibility

to low HDL-cholesterol

Variant & Polymorphism

Candidate gene
Marker	association of APOA4 with disease activity in patients with Crohn disease
Therapy target
	System Type Disorder Pubmed diabete type 1   APOA4 may provide a therapeutic target for the regulation of glucose-stimulated insulin secretion and treatment of diabetes neurology neurodegenerative alzheimer enhancing levels of APOA4 may have therapeutic potential in AD treatment

ANIMAL & CELL MODELS

the expressions of Apoa4-AS and Apoa4 are both abnormally elevated in the liver of ob/ob mice and patients with fatty liver disease