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FLASH GENE
Symbol APOA2 contributors: - updated : 04-04-2007
HGNC name apolipoprotein A-II
HGNC id 601
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • short N terminal domain and a C terminal domain with a variable number of lipid-binding amphipathic helices
    • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to rattus Apoa2 (57.14 pc)
    homolog to murine Apoa2 (61.22 pc)
    Homologene
    FAMILY
    CATEGORY regulatory , transport carrier
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    basic FUNCTION
  • involved in lipid transporter
  • stabilizing HDL (high density lipoprotein) structure by its association with lipids, and affecting the HDL metabolism
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) APOA2
    Susceptibility
  • to low HDL- cholesterol
  • to increased visceral adipose tissue in premenopausal white women
    • Variant & Polymorphism other
  • association between the T265C APOA-II polymorphism and levels of visceral adipose tissue in premenopausal white women
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS