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FLASH GENE
Symbol APCS contributors: mct - updated : 22-03-2017
HGNC name amyloid P component, serum
HGNC id 584
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a pentaxin domain
    • conjugated GlycoP
    mono polymer homomer , pentamer
    HOMOLOGY
    interspecies homolog to rattus Apcs (71.17 pc)
    homolog to murine Apcs (68.92 pc)
    Homologene
    FAMILY
  • pentraxin plasma family
    • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • may be interacting with DNA and histones and may be scavenging nuclear material released from damaged circulating cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
    • protein
  • bound preferentially to a synthetic peptide corresponding to the Ca(2+)-binding region of CRP (Swanson 1992)
  • COL4A3BP specifically binds APCS in its physiological conformations, pentamers and decamers, and START domain in COL4A3BP is important for this interaction
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS