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FLASH GENE
Symbol APCS contributors: mct - updated : 22-03-2017
HGNC name amyloid P component, serum
HGNC id 584
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   predominantly
Visualeyeanterior segmentcornea lowly
cell lineage
cell lines
fluid/secretion serum
at STAGE
physiological period perinatal
Text liver
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a pentaxin domain
    • conjugated GlycoP
    mono polymer homomer , pentamer
    HOMOLOGY
    interspecies homolog to rattus Apcs (71.17 pc)
    homolog to murine Apcs (68.92 pc)
    Homologene
    FAMILY
  • pentraxin plasma family
    • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • may be interacting with DNA and histones and may be scavenging nuclear material released from damaged circulating cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
    • protein
  • bound preferentially to a synthetic peptide corresponding to the Ca(2+)-binding region of CRP (Swanson 1992)
  • COL4A3BP specifically binds APCS in its physiological conformations, pentamers and decamers, and START domain in COL4A3BP is important for this interaction
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS