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FLASH GENE

Symbol

APCS

contributors: mct - updated : 22-03-2017

HGNC name	amyloid P component, serum
HGNC id	584

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1q23.2      Physical location : 159.557.615 - 159.558.660
Synonym name	pentaxin-related
	serum amyloid P component
	9.5S alpha-1-glycoprotein
Synonym symbol(s)	SAP, PTX2, SAMP, MGC88159

DNA

TYPE	functioning gene
STRUCTURE	1.05 kb     2 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

Y

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001639 2 - 960 NP_001630 - 223 - -

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       predominantly Visual eye anterior segment cornea   lowly

cell lineage
cell lines
fluid/secretion	serum

at STAGE

physiological period

perinatal

Text

liver

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a pentaxin domain

conjugated

GlycoP

mono polymer

homomer , pentamer

HOMOLOGY

interspecies	homolog to rattus Apcs (71.17 pc)
	homolog to murine Apcs (68.92 pc)

Homologene

FAMILY

pentraxin plasma family

CATEGORY

chaperone/stress

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION

may be interacting with DNA and histones and may be scavenging nuclear material released from damaged circulating cells

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	Ca2+

protein	bound preferentially to a synthetic peptide corresponding to the Ca(2+)-binding region of CRP (Swanson 1992)
	COL4A3BP specifically binds APCS in its physiological conformations, pentamers and decamers, and START domain in COL4A3BP is important for this interaction

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS