Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ANG contributors: mct/shn - updated : 08-09-2011
HGNC name angiogenin, ribonuclease, RNase A family, 5
HGNC id 483
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • eight cysteine and histidine and lysine residues
  • nucleolar targeting signal
    • isoforms Precursor a signal peptide of 24 AA cleaved to form the mature protein
    HOMOLOGY
    Homologene
    FAMILY
  • pancreatic ribonuclease RNase A family
    • CATEGORY enzyme , RNA associated
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • promoting the endothelial invasiveness necessary for blood vessel formation
  • required for cell proliferation induced by other angiogenic proteins such as VEGF
  • secreted ribonuclease required for stress-induced production of tiRNAs (stress-induced small RNAs) (Yamasaki 2009)
  • playing an important role in neurite extension/pathfinding and survival
  • angiogenic factor that induces neovascularization (Crabtree 2007)
  • contribute to hair growth directly, by stimulating dermal papilla cells and keratinocytes to proliferate, or indirectly, by inducing local vascularization (Zhou 2009)
  • inducing nitric oxide synthesis in endothelial cells (Trouillon 2010)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS facilitated diffusion transport
    PATHWAY
    metabolism
    signaling
    a component
  • angiogenin and tiRNAs are components of a phospho-eIF2alpha-independent stress response program (Yamasaki 2009)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding FST
  • FHL3 is a novel ANG binding partner (this interaction may provide some clues to the mechanisms of ANG-regulated cell growth and apoptosis)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ALS9
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in chronic heart failure (positively associated with age, plasma glucose, insulin, and BNP and negatively correlated with diastolic blood pressure and left ventricular ejection fraction) (Patel 2008)
    Susceptibility to amyotrophic lateral sclerosis
    Variant & Polymorphism other mutation loss of function in ALS
    Candidate gene for ALS
    Marker
    Therapy target
  • protects against dopaminergic neuronal cell death and suggests its potential as a therapy for Parkinson's disease (
    • ANIMAL & CELL MODELS
  • angiogenin-1 protein is dramatically reduced in this transgenic alpha-synuclein mouse model of Parkinson's disease (