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FLASH GENE
Symbol ANG contributors: mct/shn - updated : 08-09-2011
HGNC name angiogenin, ribonuclease, RNase A family, 5
HGNC id 483
Corresponding disease
ALS9 amyotrophic lateral sclerosis 9
Location 14q11.2      Physical location : 21.152.335 - 21.162.343
Synonym name
  • angiogenin
  • ribonuclease 5
  • epididymis luminal protein 168
  • Synonym symbol(s) RNASE5, ANGI, HEL168, MGC22466, MGC71966, RNASE4
    EC.number 3.1.27.-
    DNA
    TYPE functioning gene
    STRUCTURE 10.01 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter (TATA box)
    motif repetitive sequence   ALU
    text structure potential TATA box and two ALU repetitive sequences
    MAPPING cloned Y linked N status provisional
    Map cen - D14S261 - ANG - D14S72 - D14S1043 - qter
    Physical map
    LOC390440 14 similar to Olfactory receptor 11H6 LOC122748 14q11.2 similar to Olfactory receptor 11H6 LOC390441 14 similar to olfactory receptor LOC390442 14 similar to Olfactory receptor 11H4 TTC5 14q11.2 tetratricopeptide repeat domain 5 C14orf18 14q11.2 chromosome 14 open reading frame 18 ADPRTL2 14q11.2 ADP-ribosyltransferase (NAD+; poly(ADP-ribose) polymerase)-like 2 TEP1 14q11.2 telomerase-associated protein 1 LOC123103 14q11.2 similar to kelch-like 4 isoform 2 OSGEP 14q11.1 O-sialoglycoprotein endopeptidase APEX1 14q11.2-q12 APEX nuclease (multifunctional DNA repair enzyme) 1 C14orf9 14q11.1 chromosome 14 open reading frame 9 NP 14q13.1 nucleoside phosphorylase LOC338879 14q11.2 similar to putative pancreatic ribonuclease LOC390443 14 similar to Ribonuclease-like protein 9 precursor C14orf6 14q11.1 chromosome 14 open reading frame 6 LOC254028 14q11.2 hypothetical protein LOC254028 LOC341799 14q11.2 similar to Olfactory receptor 6S1 RNASE4 14q11.2 ribonuclease, RNase A family, 4 ANG 14q11.2 angiogenin, ribonuclease, RNase A family, 5 RANBP20P 14 RAN binding protein 20 pseudogene FAM12A 14q11.1 family with sequence similarity 12, member A FAM12B 14q11.1 family with sequence similarity 12, member B (epididymal) RNASE6 14q11.2 ribonuclease, RNase A family, k6 RNASE1 14q11 ribonuclease, RNase A family, 1 (pancreatic) RNASE3 14q11.2 ribonuclease, RNase A family, 3 (eosinophil cationic protein) RNASE2 14q11.2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) FLJ20859 14q11.2 FLJ20859 gene SLC39A2 14q11.1 solute carrier family 39 (zinc transporter), member 2 NDRG2 14q11.2 NDRG family member 2 C14orf8 14q11.2 chromosome 14 open reading frame 8 RNASE7 14q11.1 ribonuclease, RNase A family, 7 RNASE8 14q11.1 ribonuclease, RNase A family, 8 FLJ10357 14q11.2 hypothetical protein FLJ10357 ZNF219 14q11 zinc finger protein 219
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 1222 14 147 - Yamasaki (2009)
    2 - 742 14 147 - Yamasaki (2009)
  • variant 2 differs in the 5'UTR as compared to variant 1
  • encoding the same isoform
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   predominantly
    Lymphoid/Immunethymus   highly
    Nervousbrain   moderately
    Reproductivemale systemprostate  moderately
    Respiratorylung   moderately
    Skin/Tegumentskinscalp  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveinterstitialdermis  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumenthair follicle cell
    cell lineage
    cell lines SH-SY5Y and M17
    fluid/secretion
    at STAGE
    physiological period fetal
    Text
  • low expressed in developing fetus
  • highly in developing nervous system and during the neuronal differentiation of pluripotent stem cells
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • eight cysteine and histidine and lysine residues
  • nucleolar targeting signal
  • isoforms Precursor a signal peptide of 24 AA cleaved to form the mature protein
    HOMOLOGY
    Homologene
    FAMILY
  • pancreatic ribonuclease RNase A family
  • CATEGORY enzyme , RNA associated
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • promoting the endothelial invasiveness necessary for blood vessel formation
  • required for cell proliferation induced by other angiogenic proteins such as VEGF
  • secreted ribonuclease required for stress-induced production of tiRNAs (stress-induced small RNAs) (Yamasaki 2009)
  • playing an important role in neurite extension/pathfinding and survival
  • angiogenic factor that induces neovascularization (Crabtree 2007)
  • contribute to hair growth directly, by stimulating dermal papilla cells and keratinocytes to proliferate, or indirectly, by inducing local vascularization (Zhou 2009)
  • inducing nitric oxide synthesis in endothelial cells (Trouillon 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS facilitated diffusion transport
    PATHWAY
    metabolism
    signaling
    a component
  • angiogenin and tiRNAs are components of a phospho-eIF2alpha-independent stress response program (Yamasaki 2009)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding FST
  • FHL3 is a novel ANG binding partner (this interaction may provide some clues to the mechanisms of ANG-regulated cell growth and apoptosis)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ALS9
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in chronic heart failure (positively associated with age, plasma glucose, insulin, and BNP and negatively correlated with diastolic blood pressure and left ventricular ejection fraction) (Patel 2008)
    Susceptibility to amyotrophic lateral sclerosis
    Variant & Polymorphism other mutation loss of function in ALS
    Candidate gene for ALS
    Marker
    Therapy target
  • protects against dopaminergic neuronal cell death and suggests its potential as a therapy for Parkinson's disease (
  • ANIMAL & CELL MODELS
  • angiogenin-1 protein is dramatically reduced in this transgenic alpha-synuclein mouse model of Parkinson's disease (