basic FUNCTION
| involved in matrix mineralization |
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regulating both ligand availability and protein expression of P2RX7, is essential for axonal development |
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regulates inhibitory extracellular pyrophosphate through its pyrophosphatase activity to control mineral propagation in the matrix |
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prominent non-redundant roles for both PHOSPHO1 and ALPL in dentin mineralization |
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associated with earliest cementoblasts near forming acellular and cellular cementum |
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during skeletal mineralization, the building Ca2+ gradient first activates ALPL, but gradually inactivates it at high Ca2+ concentrations, toward completion of mineralization |
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is present on neuronal membranes and induces neuronal toxicity via MAPT dephosphorylation |
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GPI-anchored ALPL can likely give rise to long reaching modifications that could influence membrane processes halfway through the bilayer |