Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Orphanet | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | ALPL | contributors: mct - updated : 07-12-2016 |
HGNC name | alkaline phosphatase, liver/bone/kidney |
HGNC id | 438 |
|
DNA |
TYPE | functioning gene |
STRUCTURE | 69.43 kb 12 Exon(s) |
Genomic sequence alignment details |
---|
10 Kb 5' upstream gene genomic sequence study |
MAPPING | cloned | Y | linked | Y | status | confirmed |
Map | pter - ALPL ,HOPS1 - FUCA1 - RH - D1S57 - SLC2A1 SLC2A1 - MYCL1 - D1S15 - cen |
Authors | CEPH (91) |
RNA |
TRANSCRIPTS | type | messenger |
---|
|
EXPRESSION |
Type | widely |
tissue |
|
cell lineage
cell lines
| fluid/secretion
| |
at STAGE |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
| |
motifs/domains
| |
| |
|
conjugated | GlycoP , MetalloP |
mono polymer | homomer , dimer |
HOMOLOGY |
interspecies | homolog to murine Akp2 |
homolog to Drosophila CG5656 | |
homolog to C.elegans C15B12.4 |
Homologene |
FAMILY | alkaline phosphatase proteins family |
CATEGORY | enzyme |
SUBCELLULAR LOCALIZATION | extracellular |
plasma membrane | |
text | |
|
basic FUNCTION | |
| |
| |
| |
| |
| |
| |
|
CELLULAR PROCESS |
PHYSIOLOGICAL PROCESS | development |
text | skeletal development |
PATHWAY |
metabolism |
signaling |
metabolism phosphocalcic |
a component |
INTERACTION |
DNA |
RNA |
small molecule | metal binding, cofactor, |
|
protein | |
| |
|
cell & other |
REGULATION |
Other | is activated not simply by passive zinc binding but by an elaborate two-step mechanism via protein stabilization followed by enzyme conversion from the apo- to the holo-form with zinc loaded by ZnT complexes in the early secretory pathway |
ASSOCIATED DISORDERS |
corresponding disease(s) | HOPS1 |
related resource | Tissue Nonspecific Alkaline Phosphatase Gene Mutation Database |
Other morbid association(s) |
|
Susceptibility |
Variant & Polymorphism
| |
Candidate gene
Marker
| Therapy target
|
| |
ANIMAL & CELL MODELS |