Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ALDOC contributors: mct - updated : 28-11-2019
HGNC name aldolase C, fructose-bisphosphate
HGNC id 418
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION extracellular
    intracellular
intracellular,cytoplasm,cytosolic,granule
intracellular,cytoplasm,cytoskeleton
basic FUNCTION
  • reversibly cleaving FBP and F1-P to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate
  • potential links between the morphine-induced alteration of aldolase C and the regulation of CREB phosphorylation, a possible mechanism of morphine dependence
  • is a brain type isozyme of a glycolysis enzyme
  • ALDOC, ALDOA and ALDOB activate Wnt signaling in a GSK3B-dependent mechanism
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate , energetic
    signaling
    glycolysis
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NME1 enhanced ALDOC transcription, evidenced by increased expression of ALDOC pre-mRNA and activity of an ALDOC promoter-luciferase module
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS