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FLASH GENE

Symbol

ALDOC

contributors: mct - updated : 28-11-2019

HGNC name	aldolase C, fructose-bisphosphate
HGNC id	418

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	3.00 kb     9 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence
text structure	distal element D in the promoter region of the human aldolase C gene is the target of a cAMP-dependent regulation pathway.

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005165 9 - 1608 NP_005156 - 364 - 2014 24993527

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain hindbrain cerebellum   highly Mus musculus Respiratory respiratory tract larynx     highly Visual eye       highly

cells

System Cell Pubmed Species Stage Rna symbol Nervous Purkinje cell Mus musculus

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	liver,kidney,small intestine

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,cytosolic,granule
	intracellular,cytoplasm,cytoskeleton

basic FUNCTION	reversibly cleaving FBP and F1-P to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate
	potential links between the morphine-induced alteration of aldolase C and the regulation of CREB phosphorylation, a possible mechanism of morphine dependence
	is a brain type isozyme of a glycolysis enzyme
	ALDOC, ALDOA and ALDOB activate Wnt signaling in a GSK3B-dependent mechanism

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

carbohydrate , energetic

signaling

glycolysis

a component

INTERACTION

DNA

RNA

small molecule

protein

NME1 enhanced ALDOC transcription, evidenced by increased expression of ALDOC pre-mRNA and activity of an ALDOC promoter-luciferase module

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS