Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ALDOC contributors: mct - updated : 28-11-2019
HGNC name aldolase C, fructose-bisphosphate
HGNC id 418
Location 17q11.2      Physical location : 26.900.133 - 26.903.951
Synonym name
  • brain-type aldolase
  • fructoaldolase C
  • fructose-1,6-biphosphate triosephosphate lyase
  • zebrin II
    • EC.number 4.1.2.13
    DNA
    TYPE functioning gene
    STRUCTURE 3.00 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence
    text structure distal element D in the promoter region of the human aldolase C gene is the target of a cAMP-dependent regulation pathway.
    MAPPING cloned Y linked   status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1608 - 364 - 2014 24993527
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainhindbraincerebellum highly Mus musculus
    Respiratoryrespiratory tractlarynx  highly
    Visualeye   highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    NervousPurkinje cell Mus musculus
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text liver,kidney,small intestine
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • reversibly cleaving FBP and F1-P to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate
  • potential links between the morphine-induced alteration of aldolase C and the regulation of CREB phosphorylation, a possible mechanism of morphine dependence
  • is a brain type isozyme of a glycolysis enzyme
  • ALDOC, ALDOA and ALDOB activate Wnt signaling in a GSK3B-dependent mechanism
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate , energetic
    signaling
    glycolysis
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NME1 enhanced ALDOC transcription, evidenced by increased expression of ALDOC pre-mRNA and activity of an ALDOC promoter-luciferase module
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS