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FLASH GENE
Symbol ALDOA contributors: mct - updated : 21-11-2019
HGNC name aldolase A, fructose-bisphosphate
HGNC id 414
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , tetramer
HOMOLOGY
interspecies ortholog to murine Aldoa
intraspecies paralog to ALDOC
Homologene
FAMILY class I fructose-bisphosphate aldolase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,cytosolic,granule
intracellular,nucleus
basic FUNCTION
  • reversibly cleaving FI-P and FBP to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate
  • glycolytic enzyme which may localize both in nuclei and cytoplasm of cells
  • is a factor involved in the regulation of cells proliferation
  • functions as an oncogene in the highly metastatic pancreatic cancer
  • promotes epithelial-mesenchymal transition and tumorigenesis
  • contributed to activation of the EGFR/MAPK pathway, thus promoting cyclin D1 expression and enhancing proliferation and G1/S transition in non-small cell lung cancer
  • might play an important function in bladder cancer and its action may be though CDH1-EGFR signaling
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate , energetic
    signaling
  • glycolysis
  • fructose metabolism
    • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • control of ALDOA and VDAC2 levels by iron status of the cell
  • role of ALDOA in pancreatic cancer might attribute to its regulation of MYC, HIF1A and NFE2L2 (Nuclear Factor, Erythroid 2-Like 2), which were key regulators of glycolysis and antioxidant response control
    • cell & other
    REGULATION
    inhibited by interaction with ZNF224
    ASSOCIATED DISORDERS
    corresponding disease(s) ALDOA
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in most cancers of lung
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerlung 
    ALDOA-HIF1A axis may provide a new therapeutic target for metastatic lung cancer treatment
    ANIMAL & CELL MODELS