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FLASH GENE

Symbol

ALDOA

contributors: mct - updated : 21-11-2019

HGNC name	aldolase A, fructose-bisphosphate
HGNC id	414

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	ALDOA hemolytic anemia with aldolase deficiency
Location	16p11.2      Physical location : 30.064.490 - 30.081.734
Synonym name	fructose-1,6-bisphosphate triosephosphate-lyase
	muscle-type aldolase
	lung cancer antigen NY-LU-1
Synonym symbol(s)	ALDA, MGC10942, MGC17716, MGC17767, GSD12, HEL-S-87p
EC.number	4.1.2.13

DNA

TYPE	functioning gene
STRUCTURE	7.93 kb     14 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed V1 - - 2353 39.3 364 - 2018 29992789 NM_184041 9 - 3279 NP_908930 39.3 364 - 2018 29992789 NM_184043 9 - 1569 NP_908932 39.3 364 - 2018 29992789 NM_001127617 9 - 1630 NP_001121089 39.3 364 - 2018 29992789 NM_001243177 10 - 3433 NP_001230106 - 418 - 2018 29992789

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain         Reproductive female system uterus cervix   highly Respiratory respiratory tract larynx     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

cell cycle

cell cycle, M

Text	liver, kidney, small intestine

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

homomer , tetramer

HOMOLOGY

interspecies

ortholog to murine Aldoa

intraspecies

paralog to ALDOC

Homologene

FAMILY

class I fructose-bisphosphate aldolase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,cytosolic,granule
	intracellular,nucleus

basic FUNCTION	reversibly cleaving FI-P and FBP to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate
	glycolytic enzyme which may localize both in nuclei and cytoplasm of cells
	is a factor involved in the regulation of cells proliferation
	functions as an oncogene in the highly metastatic pancreatic cancer
	promotes epithelial-mesenchymal transition and tumorigenesis
	contributed to activation of the EGFR/MAPK pathway, thus promoting cyclin D1 expression and enhancing proliferation and G1/S transition in non-small cell lung cancer
	might play an important function in bladder cancer and its action may be though CDH1-EGFR signaling

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

carbohydrate , energetic

signaling

	glycolysis
	fructose metabolism

a component

INTERACTION

DNA

RNA

small molecule

protein	control of ALDOA and VDAC2 levels by iron status of the cell
	role of ALDOA in pancreatic cancer might attribute to its regulation of MYC, HIF1A and NFE2L2 (Nuclear Factor, Erythroid 2-Like 2), which were key regulators of glycolysis and antioxidant response control

cell & other

REGULATION

inhibited by

interaction with ZNF224

ASSOCIATED DISORDERS

corresponding disease(s)

ALDOA

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in most cancers of lung

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer lung   ALDOA-HIF1A axis may provide a new therapeutic target for metastatic lung cancer treatment

ANIMAL & CELL MODELS