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FLASH GENE
Symbol ALDH3A1 contributors: - updated : 16-02-2006
HGNC name aldehyde dehydrogenase 3 family, member A1
HGNC id 405
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , dimer
HOMOLOGY
Homologene
FAMILY aldehyde dehydrogenase,class III (fatty alcohol oxidoreductase) family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
intracellular,nucleus
basic FUNCTION
  • toxic aldehyde detoxication derived from corticosteroids biogenic amines,neurotransmitter and lipid peroxidation
  • regulatory element of the cellular defense system that protects corneal epithelium against UV-induced oxidative damage
  • may protect corneal epithelial cells against oxidative damage not only through its metabolic function but also by prolonging the cell cycle
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein , other
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor, nucleotide,
    NADPH
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS