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FLASH GENE

Symbol

ALDH3A1

contributors: - updated : 16-02-2006

HGNC name	aldehyde dehydrogenase 3 family, member A1
HGNC id	405

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol digestive esophagus       highly Digestive liver       lowly   stomach       highly Respiratory lung       highly Urinary kidney       lowly Visual eye anterior segment cornea   highly

cells

System Cell Pubmed Species Stage Rna symbol Visual epithelial cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

homomer , dimer

HOMOLOGY

Homologene

FAMILY

aldehyde dehydrogenase,class III (fatty alcohol oxidoreductase) family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus

basic FUNCTION	toxic aldehyde detoxication derived from corticosteroids biogenic amines,neurotransmitter and lipid peroxidation
	regulatory element of the cellular defense system that protects corneal epithelium against UV-induced oxidative damage
	may protect corneal epithelial cells against oxidative damage not only through its metabolic function but also by prolonging the cell cycle

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

lipid/lipoprotein , other

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding, cofactor, nucleotide,
	NADPH

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS