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FLASH GENE
Symbol ALDH3A1 contributors: - updated : 16-02-2006
HGNC name aldehyde dehydrogenase 3 family, member A1
HGNC id 405
DNA
TYPE like-sequence
STRUCTURE 10.00 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
regionally located between SMS-REPM and SMS-REPP
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
digestiveesophagus   highly
Digestiveliver   lowly
 stomach   highly
Respiratorylung   highly
Urinarykidney   lowly
Visualeyeanterior segmentcornea highly
cells
SystemCellPubmedSpeciesStageRna symbol
Visualepithelial cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , dimer
HOMOLOGY
Homologene
FAMILY aldehyde dehydrogenase,class III (fatty alcohol oxidoreductase) family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
intracellular,nucleus
basic FUNCTION
  • toxic aldehyde detoxication derived from corticosteroids biogenic amines,neurotransmitter and lipid peroxidation
  • regulatory element of the cellular defense system that protects corneal epithelium against UV-induced oxidative damage
  • may protect corneal epithelial cells against oxidative damage not only through its metabolic function but also by prolonging the cell cycle
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein , other
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor, nucleotide,
    NADPH
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS