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FLASH GENE
Symbol ALDH3A1 contributors: - updated : 16-02-2006
HGNC name aldehyde dehydrogenase 3 family, member A1
HGNC id 405
Location 17p11.2      Physical location : 19.641.299 - 19.651.746
Synonym name
  • aldehyde dehydrogenase, dimeric NADP-preferring
  • acetaldehyde dehydrogenase
    • Synonym symbol(s) ALDH3, ALDHIII, MGC10406
    EC.number 1.2.1.3
    DNA
    TYPE like-sequence
    STRUCTURE 10.00 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    regionally located between SMS-REPM and SMS-REPP
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    digestiveesophagus   highly
    Digestiveliver   lowly
     stomach   highly
    Respiratorylung   highly
    Urinarykidney   lowly
    Visualeyeanterior segmentcornea highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Visualepithelial cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY aldehyde dehydrogenase,class III (fatty alcohol oxidoreductase) family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • toxic aldehyde detoxication derived from corticosteroids biogenic amines,neurotransmitter and lipid peroxidation
  • regulatory element of the cellular defense system that protects corneal epithelium against UV-induced oxidative damage
  • may protect corneal epithelial cells against oxidative damage not only through its metabolic function but also by prolonging the cell cycle
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein , other
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor, nucleotide,
    NADPH
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS