Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol POLR2A contributors: mct - updated : 26-03-2015
HGNC name polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
HGNC id 9187
Location 17p13.1      Physical location : 7.387.697 - 7.417.935
Synonym symbol(s) POL2, POLR2, RPB1, RPO2, POLRA, RPBh1, RPOL2, RpIILS, hsRPB1, hRPB220, RNAP2
EC.number 2.7.7.6/ 2.7.7.48
DNA
TYPE functioning gene
STRUCTURE 30.24 kb     29 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
DERP6 17p13.2 S-phase 2 protein CLDN7 17p13.1 claudin 7 SLC2A4 17p13.1 solute carrier family 2 (facilitated glucose transporter), member 4 YBX2 17p11.2-p13.1 germ cell specific Y-box binding protein EIF5A 17p13-p12 eukaryotic translation initiation factor 5A GPS2 17p13 G protein pathway suppressor 2 LOC390760 17 similar to RIKEN cDNA 2810408A11 CENTB1 17p13.2 centaurin, beta 1 KCTD11 17p13.2 potassium channel tetramerisation domain containing 11 LOC339168 17p13.2 hypothetical protein LOC339168 TNK1 17p13.1 tyrosine kinase, non-receptor, 1 PLSCR3 17p13.2 phospholipid scramblase 3 MGC40107 17p13.2 hypothetical protein MGC40107 NLGN2 17p13 neuroligin 2 LOC374768 17p13.2 hypothetical protein LOC374768 LOC201243 17p13.2 hypothetical protein LOC201243 LOC388329 17 similar to ENSANGP00000015193 FLJ36878 17p13.2 hypothetical protein FLJ36878 LOC388330 17 LOC388330 FGF11 17p13.1 fibroblast growth factor 11 CHRNB1 17p13.1 cholinergic receptor, nicotinic, beta polypeptide 1 (muscle) ZBTB4 17p13.2 zinc finger and BTB domain containing 4 POLR2A 17p13.1 polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
29 - 6738 - 1970 - -
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon lowly
 intestinesmall intestine  moderately
 mouthtongue  highly
Lymphoid/Immunethymus   lowly
Reproductivefemale systembreastmammary gland predominantly
Respiratorylung   lowly
 respiratory tractlarynx  moderately
Visualeye   lowly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cell lineage
cell lines
fluid/secretion blood
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • phosphorylated C-terminal domain
  • zinc-finger
  • C terminal repeat sequence consisting of 52 repeats of the consensus motif (YSPTSPS) referred to as the C terminal domain CTD and is critical for the regulation of gene expression states
  • conjugated PhosphoP
    HOMOLOGY
    interspecies ortholog to rattus Polr2a
    ortholog to murine Polr2a
    ortholog to drosophila RpII215
    ortholog to C. elegans ama-1
    Homologene
    FAMILY
  • RNA polymerase beta' chain family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • DNA-dependent RNA polymerase catalyzing the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
  • may play a role in cyclobutane pyrimidine dimers damage recognition
  • CELLULAR PROCESS nucleotide, repair
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • RNA polymerase II composed of 12 different subunits
  • DNA-directed RNA polymerase II, core complex
  • INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • FNBP3
  • NSAP1
  • SAFB
  • MYB cooperates with CASP8AP2 in foci associated with active POLR2A, leading to enhancement of MYB-dependent gene activation
  • histone N-terminal tails interfere with nucleosome traversal by POLR2A
  • direct interaction of PHF8 with the C-terminal domain of POLR2A
  • Mediator complex interacts extensively with POLR2A, suggesting that activator-induced structural shifts within Mediator trigger activation of stalled Pol II
  • DBIRD complex acts at the interface between mRNP particles and POLR2A, integrating transcript elongation with the regulation of alternative splicing
  • AGO1 and AGO2 facilitate spliceosome recruitment and modulate POLR2A elongation rate, thereby affecting alternative splicing
  • role for SNAPC1 as a general transcriptional coactivator that functions through elongating POLR2A
  • dynamic interaction of SNAPC1 with elongating POLR2A during activation of the FOS gene by EGF
  • interaction of CDK12 with CCNK is required for the phosphorylation of the C-terminal domain of RNA polymerase II
  • BRD4 regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells
  • through cooperation with POLR2A and KDM6A, SUPT6H orchestrates removal of H3K27me3, thus controlling developmental gene expression and cell differentiation
  • nuclear DPP4 interacted with a genomic flanking region of the gene for POLR2A, a subunit of RNA polymerase II
  • RECQL5 interacts with POLR2A and inhibits transcription of protein-encoding genes
  • nuclear EIF2C1 regulates the expression of EIF2C1-bound genes that are implicated in oncogenic pathways including cell cycle progression, growth, and survival
  • PPP1R10 regulates POLR2A-mediated gene expression and is necessary for developmental growth
  • DGCR8 physically interacted with ERCC6 and POLR2A
  • cell & other
    REGULATION
    activated by phosphorylation
    Other regulated by positive transcription elongation factor b (CDK9) in association with bromodomain-containing protein 4 (BRD4)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS