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FLASH GENE
Symbol CHRM1 contributors: mct - updated : 16-11-2015
HGNC name cholinergic receptor, muscarinic 1
HGNC id 1950
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
seven transmembrane segments (7TM) receptor
secondary structure
  • 14 AAs, Asn422 to Cys435, C-terminal to transmembrane (TM) helix 7 form potentially an eighth (H8) helix, associated with the cytoplasmic surface of the cell membrane in the active state of the receptor (
    • HOMOLOGY
    Homologene
    FAMILY G protein coupled receptor superfamily, k1 cholinergic receptor
    CATEGORY receptor , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract
  • facilitate cue detection behaviors and is both necessary and sufficient for most direct effects of ACh on pyramidal neuron excitability
  • role in mediating enteric cholinergic neurotransmission
  • CHRM1, and CHRM4, are the major muscarinic ACh receptors subtypes responsible for direct cholinergic modulation of the excitatory hippocampal circuit
  • CHRM1 and CHRM3, are essential for rapid eye movement (REM) sleep
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with caveolins (caveolins play a role in the attenuation of CHRM1 intracellular trafficking to and from the plasma membrane)
  • PPP1R9B is a RGS8-interacting protein (CHRM1 and PPP1R9B compete for binding to RGS8)
  • indirect binding of RGS8 to the CHRM1 through PPP1R9B for an efficient regulatory function
  • ACCN2 is a novel target for muscarinic signaling, and CHRM1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in schizophrenia
    tumoral   deletion    
    in neuroblastoma
    Susceptibility
  • to numerous inflammatory diseases, including sepsis, Crohn disease and pancreatitis
    • Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Chrm1 and Chrm3 double knockout chronically diminishes REM sleep to an almost undetectable level