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FLASH GENE

Symbol

CHRM1

contributors: mct - updated : 16-11-2015

HGNC name	cholinergic receptor, muscarinic 1
HGNC id	1950

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000738 2 - 2863 - 460 - 2001 11855742

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon   highly Homo sapiens Nervous brain forebrain cerebral cortex   highly Homo sapiens   brain limbic system hippocampus   highly Homo sapiens Reproductive male system prostate

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron Homo sapiens Nervous pyramidal cell Homo sapiens Skin/Tegument melanocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

seven transmembrane segments (7TM) receptor

secondary structure	14 AAs, Asn422 to Cys435, C-terminal to transmembrane (TM) helix 7 form potentially an eighth (H8) helix, associated with the cytoplasmic surface of the cell membrane in the active state of the receptor (

HOMOLOGY

Homologene

FAMILY

G protein coupled receptor superfamily, k1 cholinergic receptor

CATEGORY

receptor , transport channel

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract
	facilitate cue detection behaviors and is both necessary and sufficient for most direct effects of ACh on pyramidal neuron excitability
	role in mediating enteric cholinergic neurotransmission
	CHRM1, and CHRM4, are the major muscarinic ACh receptors subtypes responsible for direct cholinergic modulation of the excitatory hippocampal circuit
	CHRM1 and CHRM3, are essential for rapid eye movement (REM) sleep

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacting with caveolins (caveolins play a role in the attenuation of CHRM1 intracellular trafficking to and from the plasma membrane)
	PPP1R9B is a RGS8-interacting protein (CHRM1 and PPP1R9B compete for binding to RGS8)
	indirect binding of RGS8 to the CHRM1 through PPP1R9B for an efficient regulatory function
	ACCN2 is a novel target for muscarinic signaling, and CHRM1

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   in schizophrenia tumoral   deletion     in neuroblastoma

Susceptibility

to numerous inflammatory diseases, including sepsis, Crohn disease and pancreatitis

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Chrm1 and Chrm3 double knockout chronically diminishes REM sleep to an almost undetectable level