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FLASH GENE

Symbol

PPY

contributors: - updated : 16-02-2006

HGNC name	pancreatic polypeptide
HGNC id	9327

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	17q21.2      Physical location : 42.018.172 - 42.019.833
Genatlas name	pancreatic polypeptide hormone precursor
Synonym symbol(s)	PNP

DNA

TYPE	anonymous DNA segment
STRUCTURE	1.00 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine pancreas islet of Langerhans

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine

cells

System Cell Pubmed Species Stage Rna symbol Endocrine PP

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a signal peptide
	a pancreatic polypeptide sequence separated from the pancreatic icosapeptide sequence by a cleavage site, followed by a C terminal tyrosinamide

isoforms

Precursor

95 aa polypeptide precursor cleaved into two peptide products; the active hormone of 36 aa and an icosapeptide of unknown function

HOMOLOGY

Homologene

FAMILY

NPY family

CATEGORY

signaling hormone

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	regulator of pancreatic and gastrointestinal functions
	may be important in the regulation of food intake

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS