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FLASH GENE
Symbol FGF6 contributors: mct - updated : 25-02-2015
HGNC name fibroblast growth factor 6
HGNC id 3684
PROTEIN
PHYSICAL PROPERTIES basic
STRUCTURE
motifs/domains
HOMOLOGY
intraspecies homolog to HST oncogene
Homologene
FAMILY
  • heparin-binding growth factors family
  • FGF4 subfamily
    • CATEGORY protooncogene , signaling growth factor
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • may be playing a role in muscle regeneration or differentiation
  • has likely a dual function in muscle regeneration, stimulating myoblast proliferation/migration and muscle differentiation/hypertrophy in a dose-dependent manner
  • perichondrial FGF1, FGF2, FGF6, FGF7, FGF9, FGF18, FGF21, fGF22 regulate growth plate chondrogenesis
  • may be considered a regulator of bone metabolism as shown by its activity on both osteoblasts and osteoclasts
  • crucial and unexpected role for FGF6 in muscle integrity and muscle protection against mechanical stress
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • TGFB1-SMAD4-FGF6 signaling cascade plays a crucial role in myogenic cell fate determination and lineage progression during tongue myogenesis
    • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • specific relationship between FGF6 and SPRY2, both being known for their particular involvement in myogenesis
  • key ligand for fibroblast growth factor receptor 4 (FGFR4) during muscle regeneration
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in prostatic intraepithelial neoplasia and prostate cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS