Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol FGF6 contributors: mct - updated : 25-02-2015
HGNC name fibroblast growth factor 6
HGNC id 3684
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Reproductivemale systemtestis   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, pregnancy
Text pregnancy, embryo, during embryonic development
PROTEIN
PHYSICAL PROPERTIES basic
STRUCTURE
motifs/domains
HOMOLOGY
intraspecies homolog to HST oncogene
Homologene
FAMILY
  • heparin-binding growth factors family
  • FGF4 subfamily
    • CATEGORY protooncogene , signaling growth factor
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • may be playing a role in muscle regeneration or differentiation
  • has likely a dual function in muscle regeneration, stimulating myoblast proliferation/migration and muscle differentiation/hypertrophy in a dose-dependent manner
  • perichondrial FGF1, FGF2, FGF6, FGF7, FGF9, FGF18, FGF21, fGF22 regulate growth plate chondrogenesis
  • may be considered a regulator of bone metabolism as shown by its activity on both osteoblasts and osteoclasts
  • crucial and unexpected role for FGF6 in muscle integrity and muscle protection against mechanical stress
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • TGFB1-SMAD4-FGF6 signaling cascade plays a crucial role in myogenic cell fate determination and lineage progression during tongue myogenesis
    • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • specific relationship between FGF6 and SPRY2, both being known for their particular involvement in myogenesis
  • key ligand for fibroblast growth factor receptor 4 (FGFR4) during muscle regeneration
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in prostatic intraepithelial neoplasia and prostate cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS