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FLASH GENE
Symbol ACTA1 contributors: mct/npt - updated : 13-05-2014
HGNC name actin, alpha 1, skeletal muscle
HGNC id 129
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • CAG box motif interacting with transacting transcriptional factors
    • mono polymer polymer
    HOMOLOGY
    interspecies homolog to murine Acta1
    intraspecies homolog to ACTC1
    Homologene
    FAMILY
  • actin family
    • CATEGORY motor/contractile , structural protein
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • structural protein, major constituent of the contractile apparatus involved in cell motility, structure and integrity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TNNT1 and TPM3 and ultimatily regulating the development of muscle contraction
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ACTM , NEM3 , CFTD1
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS