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FLASH GENE
Symbol ACTA1 contributors: mct/npt - updated : 13-05-2014
HGNC name actin, alpha 1, skeletal muscle
HGNC id 129
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Respiratoryrespiratory tractlarynx  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularsmooth   
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • CAG box motif interacting with transacting transcriptional factors
    • mono polymer polymer
    HOMOLOGY
    interspecies homolog to murine Acta1
    intraspecies homolog to ACTC1
    Homologene
    FAMILY
  • actin family
    • CATEGORY motor/contractile , structural protein
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • structural protein, major constituent of the contractile apparatus involved in cell motility, structure and integrity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TNNT1 and TPM3 and ultimatily regulating the development of muscle contraction
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ACTM , NEM3 , CFTD1
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS