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FLASH GENE

Symbol

ACP5

contributors: mct/pgu - updated : 17-09-2010

HGNC name	acid phosphatase 5, tartrate resistant
HGNC id	124

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       highly Lymphoid/Immune spleen       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone       Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune dendritic cell Lymphoid/Immune macrophage Skeleton osteoclast

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	putative signal sequence of 19 AA
	two potential glycosylation sites

conjugated

GlycoP

mono polymer

monomer , dimer

HOMOLOGY

interspecies

homolog to murine Acp5

Homologene

FAMILY	metallophosphoesterase superfamily
	purple acid phosphatase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,lumen
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,lysosome
	intracellular,cytoplasm,cytosolic

basic FUNCTION	catalyzing the conversion of orthophosphoric monoester to alcohol and orthophosphate
	has an important role in the presentation of antigens to T cells
	important for polarizing responses in na
	ve T cells to antigen-presented dendritic cells
	essential for normal skeletal development, and has an important role in the metabolism of collagen
	acid phosphatase, having a dual role and involved in the regulation of the biological activity of the bone matrix phosphoproteins osteopontin and bone sialoprotein and the intracellular collagen degradation
	role in regulating osteoclast migration on post-translationally modified SPP1

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

disulfide-linked two-subunit structure

INTERACTION

DNA

RNA

small molecule	metal binding, cofactor,
	two iron Fe2+

protein	interacting with OPN and BSP
	link between ACP5 activity and interferon metabolism, emphasizing the importance of the type I interferon response in autoimmunity
	NFATC1 is a key transcription factor, playing a role in regulating expression of osteoclast-specific downstream target genes such as ACP5 and OSCAR

cell & other

REGULATION

activated by

STAT6 (in the absence of TNFSF11 and osteoclast differentiation, STAT6 binds the ACP5 promoter after IL4 treatment and directly enhances its expression)

repressed by

IL4 (down-regulates expression of ACP5 in mature osteoclasts)

ASSOCIATED DISORDERS

corresponding disease(s)

SPENCD1

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in hepatocellular carcinoma

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

TRACP(-/-) mice have impaired maturation and defective Th1 responses