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FLASH GENE

Symbol

ACADS

contributors: mct/npt - updated : 13-04-2018

HGNC name	acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain
HGNC id	90

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	14.14 kb     10 Exon(s)

10 Kb 5' upstream gene genomic sequence study

motif

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 10 - 1934 41.7 412 - Pedersen (2008)

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon   highly   liver         Lymphoid/Immune spleen       highly Reproductive female system ovary     highly   female system placenta     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow       Connective bone       Muscular striatum skeletal     Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol   digestive

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

homomer , tetramer

HOMOLOGY

interspecies	ortholog to rattus Acads
	ortholog to murine Acads

Homologene

FAMILY

acyl-CoA dehydrogenase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,matrix
	intracellular,cytoplasm,organelle,Golgi

basic FUNCTION	catalyzing the initial step of the mitochondrial fatty acid beta-oxidation pathway
	transferring an electron to ETF

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

electron transport

PATHWAY

metabolism

energetic , lipid/lipoprotein

signaling

fatty acid beta oxidation

a component

INTERACTION

DNA

RNA

small molecule	cofactor, nucleotide,
	FAD+

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

ACADS

related resource

MITOP database

Susceptibility

ethylmalonic aciduria

Variant & Polymorphism	with a frequent variant alleles 511C-511C>T, 625G>A, T625G-a conferring together susceptibility to ethylmalonic aciduria

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS