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FLASH GENE
Symbol ACADS contributors: mct/npt - updated : 13-04-2018
HGNC name acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain
HGNC id 90
Corresponding disease
ACADS ACADS deficiency
Location 12q24.31      Physical location : 121.163.570 - 121.177.810
Synonym name
  • butyryl-CoA dehydrogenase
  • unsaturated acyl-CoA reductase
    • Synonym symbol(s) SCAD, ACAD3
    EC.number 1.3.99.2
    DNA
    TYPE functioning gene
    STRUCTURE 14.14 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    motif
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 1934 41.7 412 - Pedersen (2008)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
     liver    
    Lymphoid/Immunespleen   highly
    Reproductivefemale systemovary  highly
     female systemplacenta  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Connectivebone   
    Muscularstriatumskeletal  
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
     digestive
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , tetramer
    HOMOLOGY
    interspecies ortholog to rattus Acads
    ortholog to murine Acads
    Homologene
    FAMILY
  • acyl-CoA dehydrogenase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • catalyzing the initial step of the mitochondrial fatty acid beta-oxidation pathway
  • transferring an electron to ETF
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism energetic , lipid/lipoprotein
    signaling
  • fatty acid beta oxidation
    • a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
  • FAD+
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ACADS
    related resource MITOP database
    Susceptibility ethylmalonic aciduria
    Variant & Polymorphism with a frequent variant alleles 511C-511C>T, 625G>A, T625G-a conferring together susceptibility to ethylmalonic aciduria
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS