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FLASH GENE

Symbol

ACADM

contributors: mct/npt - updated : 22-06-2009

HGNC name	acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain
HGNC id	89

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	39.31 kb     12 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

Y

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 12 - 2615 isoform a 43.6 421 - O'Reilly (2005) variant 3 13 - 2627 43.64 425 - O'Reilly (2005)

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive liver

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose     highly Muscular striatum cardiac   highly Muscular striatum skeletal   highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N terminal all-alpha domain
	transmembrane domain
	C terminal all-alpha, four helical up-and-down bundle

mono polymer

homomer , tetramer

HOMOLOGY

Homologene

FAMILY

acyl-CoA dehydrogenase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,matrix

basic FUNCTION

acyl-CoA dehydrogenase, medium chain (C6-C12), fatty acid beta-oxidation, first step, transferring an electron to ETF

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

energetic , lipid/lipoprotein

signaling

a component

INTERACTION

DNA

RNA

small molecule	cofactor, nucleotide,
	FAD+

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

ACADM

related resource

MITOP database

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS