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FLASH GENE
Symbol ACADM contributors: mct/npt - updated : 22-06-2009
HGNC name acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain
HGNC id 89
Corresponding disease
ACADM medium-chain acylcarnitine deficiency
Location 1p31.1      Physical location : 76.190.042 - 76.229.353
Synonym name medium-chain acyl-CoA dehydrogenase
Synonym symbol(s) MCAD, ACAD1, MCADH, FLJ18227, FLJ93013, FLJ99884
EC.number 1.3.99.3
DNA
TYPE functioning gene
STRUCTURE 39.31 kb     12 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status provisional
Physical map
LOC339468 1p31.1 hypothetical protein LOC339468 LOC126811 1p31.1 similar to keratin 8; cytokeratin 8; keratin, type II cytoskeletal 8 MGC22773 1p31.1 hypothetical protein MGC22773 FPGT 1p31.1 fucose-1-phosphate guanylyltransferase CARK DKFZp547I048 1p31.1 hypothetical protein DKFZp547I048 CRYZ 1p31-p22 crystallin, zeta (quinone reductase) LOC388640 1 similar to crystallin, zeta; NADPH:quinone reductase LOC127253 1p31.1 hypothetical protein BC009514 LOC148864 1p31.1 similar to LIM homeo domain transcription factor MGC34032 1p31.1 hypothetical protein MGC34032 LOC388641 1 LOC388641 LOC343221 1p31.1 similar to KIAA0433 protein ACADM 1p31 acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain DLSTP 1p31 dihydrolipoamide S-succinyltransferase pseudogene (E2 component of 2-oxo-glutarate complex) RABGGTB 1p31 Rab geranylgeranyltransferase, beta subunit MSH4 1p31 mutS homolog 4 (E. coli) ASB17 1p31.1 ankyrin repeat and SOCS box-containing 17 SIAT7C 1p31.1 sialyltransferase 7 ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) C LOC388642 1 similar to Triosephosphate isomerase (TIM) LOC388643 1 LOC388643 SIAT7E 1p31.1 sialyltransferase 7 ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) E LOC256483 1p31.1 hypothetical LOC256483 PIGK 1p31.1 phosphatidylinositol glycan, class K AK5 1p31 adenylate kinase 5 DKFZP564I052 USP33 1p31.1 ubiquitin specific protease 33 FLJ35093 1p31.1 FLJ35093 protein LOC91624 FUBP1 1p31.1 far upstream element (FUSE) binding protein 1 DNAJB4 1p31.1 DnaJ (Hsp40) homolog, subfamily B, member 4 LOC339425 1p31.1 similar to Nit protein 2 GIPC2 1p31.1 PDZ domain protein GIPC2 LOC388644 1 hypothetical gene supported by AK091757 PTGFR 1p31.1 prostaglandin F receptor (FP) C1orf29 1p31.1 chromosome 1 open reading frame 29 IFI44 1p31.1 interferon-induced protein 44 LOC343295 1p31.1 similar to Nuclear protein SkiP (Ski-interacting protein) (SNW1 protein) (Nuclear receptor coactivator NCoA-62) ELTD1 1p33-p32 EGF, latrophilin and seven transmembrane domain containing 1 LOC149050 1p31.1 similar to phosphoserine aminotransferase isoform 1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 2615 43.6 421 - O'Reilly (2005)
13 - 2627 43.64 425 - O'Reilly (2005)
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveliver    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
Muscularstriatumcardiac highly
Muscularstriatumskeletal highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal all-alpha domain
  • transmembrane domain
  • C terminal all-alpha, four helical up-and-down bundle
  • mono polymer homomer , tetramer
    HOMOLOGY
    Homologene
    FAMILY
  • acyl-CoA dehydrogenase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    basic FUNCTION
  • acyl-CoA dehydrogenase, medium chain (C6-C12), fatty acid beta-oxidation, first step, transferring an electron to ETF
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism energetic , lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
  • FAD+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ACADM
    related resource MITOP database
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS