Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ABL2 contributors: mct - updated : 22/11/2008
HGNC name v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)
HGNC id 77
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two Src homology domain SH3, SH2 and a tyrosine kinase catalytic domain
  • two filamentous F and G actin-binding domain at the C terminus
    • HOMOLOGY
    interspecies homolog to Abelson murine leukemia viral (v-abl) oncogene 2
    intraspecies homolog to ABL1
    Homologene
    FAMILY
  • TYR family of protein kinase
  • ABL subfamily
    • CATEGORY enzyme , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • non receptor, tyrosine kinase regulating actin cytoskeletal structure
  • membrane-anchored nonreceptor tyrosine kinase that is a novel mediator of SEMA3F-induced RhoA inactivation and collapsing activity
  • has a role in cytoskeletal rearrangements by its C-terminal F-actin- and microtubule-binding sequences
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ARGBP2, potentially linking Abl family kinases and the actin cytoskeleton
  • interacting with SEMA3F (in response to SEMA3F, is recruited to bind plexin A1 and to phosphorylate and activate p190RhoGAP directly, resulting in RhoA inactivation and cofilin-mediated cytoskeleton collapse)
  • interacting with SIVA1 (functional significance of the ABL2-SIVA1 interaction is supported by the finding that ABL2 is activated by oxidative stress and that this response involves ABL2-mediated phosphorylation of SIVA1 on Tyr(48) (Cao 2001)
    • cell & other
    REGULATION
    activated by oxidative stress induces apoptosis by a SIVA1-dependent mechanism (Cao 2001)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    with ETV6 in t(1;12)(q25;p13) in acute myeloid leukmia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS