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FLASH GENE
Symbol ABL2 contributors: mct - updated : 22/11/2008
HGNC name v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)
HGNC id 77
Location 1q24-q25      Physical location : 179.068.462 - 179.198.819
Synonym name
  • abelson related gene
  • Abelson murine leukemia viral (v-abl) oncogene homolog 2
    • Synonym symbol(s) ABLL, ARG, FLJ22224, FLJ31718, FLJ41441
    EC.number 2.7.10.2
    DNA
    TYPE functioning gene
    STRUCTURE 130.30 kb     11 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 12175 128 1182 - Kruh, Olsen (2006)
    including exon 1B
    11 - 11864 - 1146 - Kruh, Olsen (2006)
    including exon 1A
    12 - 11927 - 1167 - Olsen (2006)
    - - 2140 - 1146 - Bianchi (2008)
    - - 11635 - 1064 - Bianchi (2008)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
     salivary gland   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    Muscularstriatumskeletal highly
    cell lineage
    cell lines tumors cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text developing neurons
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two Src homology domain SH3, SH2 and a tyrosine kinase catalytic domain
  • two filamentous F and G actin-binding domain at the C terminus
    • HOMOLOGY
    interspecies homolog to Abelson murine leukemia viral (v-abl) oncogene 2
    intraspecies homolog to ABL1
    Homologene
    FAMILY
  • TYR family of protein kinase
  • ABL subfamily
    • CATEGORY enzyme , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • non receptor, tyrosine kinase regulating actin cytoskeletal structure
  • membrane-anchored nonreceptor tyrosine kinase that is a novel mediator of SEMA3F-induced RhoA inactivation and collapsing activity
  • has a role in cytoskeletal rearrangements by its C-terminal F-actin- and microtubule-binding sequences
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ARGBP2, potentially linking Abl family kinases and the actin cytoskeleton
  • interacting with SEMA3F (in response to SEMA3F, is recruited to bind plexin A1 and to phosphorylate and activate p190RhoGAP directly, resulting in RhoA inactivation and cofilin-mediated cytoskeleton collapse)
  • interacting with SIVA1 (functional significance of the ABL2-SIVA1 interaction is supported by the finding that ABL2 is activated by oxidative stress and that this response involves ABL2-mediated phosphorylation of SIVA1 on Tyr(48) (Cao 2001)
    • cell & other
    REGULATION
    activated by oxidative stress induces apoptosis by a SIVA1-dependent mechanism (Cao 2001)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    with ETV6 in t(1;12)(q25;p13) in acute myeloid leukmia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS