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FLASH GENE

Symbol

SERPINA3

contributors: mct/npt - updated : 27-06-2012

HGNC name	serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
HGNC id	16

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

AACT

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --other   aberrantly expressed during melanoma progression and predicts poor survival for patients with metastatic melanoma constitutional     --over   SERPINA3 mRNA is overexpressed in the placentas of preeclamptic/IUGR pregnancies compared with controls, along with hypomethylation of the 5&8242; gene region

Susceptibility

to Alzheimer disease and to Parkinson disease

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed dermatology skin   potential therapeutic value in inflammation-mediated tissue damage, and for the treatment of recalcitrant nonhealing skin ulcers

ANIMAL & CELL MODELS