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FLASH GENE
Symbol SERPINA3 contributors: mct/npt - updated : 27-06-2012
HGNC name serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
HGNC id 16
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • high molecular weight proteinase inhibitor
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to rattus spin2c
    homolog to murine Spin2c
    Homologene
    FAMILY
  • serpin superfamily
    • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,nucleus
    basic FUNCTION
  • inhibits the activity of cathepsin G (release of neutrophil cathepsin G can destroy the vascular matrix through degradation, platelet aggregation and coagulation disorders)
  • inhibitor that controls proMMP-9 activation in skin tissue
  • would likely contribute to reducing tissue damage by proteases that are released at the site of skin injury
  • in the context of chronic inflammatory diseases, therapeutic SERPINA3 might protect tissue from undesirable destructive side effects of leukocyte-derived proteases
  • is a typical acute-phase protein secreted into the circulation during acute and chronic inflammation
  • has anti-inflammatory and anti-apoptotic functions
  • importance of SERPINA3 in the homeostasis of placental development
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) AACT
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    aberrantly expressed during melanoma progression and predicts poor survival for patients with metastatic melanoma
    constitutional     --over  
    SERPINA3 mRNA is overexpressed in the placentas of preeclamptic/IUGR pregnancies compared with controls, along with hypomethylation of the 5&8242; gene region
    Susceptibility to Alzheimer disease and to Parkinson disease
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    dermatologyskin 
    potential therapeutic value in inflammation-mediated tissue damage, and for the treatment of recalcitrant nonhealing skin ulcers
    ANIMAL & CELL MODELS