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FLASH GENE

Symbol

SERPINA3

contributors: mct/npt - updated : 27-06-2012

HGNC name	serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
HGNC id	16

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster, opposite orientation
text	in opposite orientation to SERPINA1
STRUCTURE	11.68 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
	Binding site   transcription factor
text structure	promoter of SERPINA3 is transcriptionally activated by three transcription factors (TFs) (SP1, MZF1 and ZBTB7B)
	in normal placenta, the SERPINA3 promoter is methylated

MAPPING

cloned

Y

linked

Y

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001085 5 - 1629 NP_001076 45 423 - 2004 15014966

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       highly Endocrine pancreas       highly Urinary bladder       highly

cell lineage
cell lines
fluid/secretion	plasma

at STAGE

physiological period

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

high molecular weight proteinase inhibitor

conjugated

GlycoP

HOMOLOGY

interspecies	homolog to rattus spin2c
	homolog to murine Spin2c

Homologene

FAMILY

serpin superfamily

CATEGORY

enzyme , regulatory

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,nucleus

basic FUNCTION	inhibits the activity of cathepsin G (release of neutrophil cathepsin G can destroy the vascular matrix through degradation, platelet aggregation and coagulation disorders)
	inhibitor that controls proMMP-9 activation in skin tissue
	would likely contribute to reducing tissue damage by proteases that are released at the site of skin injury
	in the context of chronic inflammatory diseases, therapeutic SERPINA3 might protect tissue from undesirable destructive side effects of leukocyte-derived proteases
	is a typical acute-phase protein secreted into the circulation during acute and chronic inflammation
	has anti-inflammatory and anti-apoptotic functions
	importance of SERPINA3 in the homeostasis of placental development

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

AACT

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --other   aberrantly expressed during melanoma progression and predicts poor survival for patients with metastatic melanoma constitutional     --over   SERPINA3 mRNA is overexpressed in the placentas of preeclamptic/IUGR pregnancies compared with controls, along with hypomethylation of the 5&8242; gene region

Susceptibility

to Alzheimer disease and to Parkinson disease

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed dermatology skin   potential therapeutic value in inflammation-mediated tissue damage, and for the treatment of recalcitrant nonhealing skin ulcers

ANIMAL & CELL MODELS