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FLASH GENE
Symbol A2M contributors: - updated : 29-09-2006
HGNC name alpha-2-macroglobulin
HGNC id 7
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
cell lineage
cell lines
fluid/secretion plasma
at STAGE
physiological period embryo, fetal
Text liver
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • peptide stretch, called the 'bait region' with specific cleavage sites for different proteinases
    • secondary structure two pairs of disulfide linked chains
    mono polymer homomer , tetramer
    HOMOLOGY
    interspecies homolog to murine A2m
    Homologene
    FAMILY
  • protease inhibitor I39 (alpha-2- macroglobulin) family
    • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION extracellular
    text serum
    basic FUNCTION
  • serum protease inhibitor mediating the clearance and degradation of A-beta, the major component of beta-amyloid deposits
  • protease inhibitor and cytokine transporter
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text cytokine transporter
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associating to TGFBs and forming latent complexes
  • associating with PDGFVB
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) A2M
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    in clear cell renal carcinomas with poor outcome
    Susceptibility to Alzheimer disease (AD5)
    Variant & Polymorphism other
  • polymorphisms significantly associated with Alzheimer disease
  • A2M gene deletion associated with overweight and obesity in Thais
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS