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FLASH GENE

Symbol

A2M

contributors: - updated : 29-09-2006

HGNC name	alpha-2-macroglobulin
HGNC id	7

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000014 36 - 4678 NP_000005 - 1474 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic

cell lineage
cell lines
fluid/secretion	plasma

at STAGE

physiological period

embryo, fetal

Text

liver

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

peptide stretch, called the 'bait region' with specific cleavage sites for different proteinases

secondary structure

two pairs of disulfide linked chains

mono polymer

homomer , tetramer

HOMOLOGY

interspecies

homolog to murine A2m

Homologene

FAMILY

protease inhibitor I39 (alpha-2- macroglobulin) family

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION	extracellular
text	serum

basic FUNCTION	serum protease inhibitor mediating the clearance and degradation of A-beta, the major component of beta-amyloid deposits
	protease inhibitor and cytokine transporter

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

text	cytokine transporter

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	associating to TGFBs and forming latent complexes
	associating with PDGFVB

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

A2M

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral       loss of function in clear cell renal carcinomas with poor outcome

Susceptibility

to Alzheimer disease (AD5)

Variant & Polymorphism other	polymorphisms significantly associated with Alzheimer disease
	A2M gene deletion associated with overweight and obesity in Thais

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS