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FLASH GENE
Symbol A1BG contributors: mct - updated : 27-10-2011
HGNC name alpha-1-B glycoprotein
HGNC id 5
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • five Ig-like V-type (immunoglobulin-like) domains
    • conjugated GlycoP
    mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • immunoglobulin C-2 type family
    • CATEGORY receptor
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus
    basic FUNCTION
  • potentially A1BG-CRISP3 complex displays a similar function in protecting the circulation from a potentially harmful effect of free CRISP3
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexed with CRISP3
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CRISP3 is a specific and high-affinity ligand of A1BG
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in endometrium from ectopic when compared with intrauterine pregnancies
    tumoral     --over  
    in cancerous pancreatic juice from pancreatic ductal adenocarcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • potential biomarker in pancreatic cancer
  • a 13.8&
    • 8201;kDa A1BG fragment having a high discriminatory power for steroid resistance in pediatric nephrotic syndrome, but is only present in a subset of patients
    Therapy target
    ANIMAL & CELL MODELS