| basic FUNCTION
| monocyte, chemoattractant, activated T cell and dendritic cell |
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involved in cytoskeletal regulation |
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one of the major HIV-suppressive factors produced by CD8+ T cells |
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playing a role as an important mediator of virus-induced inflammation |
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playing a role in eosinophil recruitment in inflammatory states such as occurs in the asthmatic lung |
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inhibiting stem cell proliferation |
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contributing to intracellular signaling and other chemokine receptor function |
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CCL3/CCR1 axis may have a role in the spread of tumoral cells to the lymph nodes and also in the local host defense against the tumor  |
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with CCL4, may directly or indirectly affect neuronal excitability, and are implicated in the etiology and pathogenesis of temporal lobe epilepsy |
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its expression not only reduces viral pathogenicity but also enhances immunogenicity by recruiting dendritic cells and B cells to the site of immunization, the lymph nodes, and the blood |
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CCL3 and CCL4 are chemokines crucial for immune responses towards infection and inflammation |
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for CCL3 activation of migration, no release of intracellular calcium is necessary |
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under conditions of acute inflammation leukocyte-derived CCL3 can induce neutrophil chemotaxis toward the atherosclerotic plaque, thereby accelerating lesion formation |
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CCL2/CCL3 are small chemotactic proteins that have been found in several kinds of tumor tissue samples and function as key regulators of cancer progression |
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chemokine CCL3 is an hippocampal neuromodulator able to regulate synaptic plasticity mechanisms involved in learning and memory functions |
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Tregs produced both CCL3 and CCL4 in response to stimulation, and production of these chemokines was critical for migration of target T cells |
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CCL5 and CCL3 are critical for immune surveillance and inflammation |
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role of CCL3 in the maintenance of homeostatic hematopoiesis that should be evaluated when targeting CCL3 signaling for the treatment of hematologic malignancy |
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CCL3 could up-regulate CD4+T cells to mediate the inflammatory response of rheumatoid arthritis (RA) |
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important chemokine implicated in both immune surveillance and tolerance, that has emerged as a prognostic biomarker in both solid and hematological malignancies |
