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FLASH GENE
Symbol LLGL1 contributors: mct/npt - updated : 10-03-2010
HGNC name lethal giant larvae homolog 1 (Drosophila)
HGNC id 6628
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • several conserved functional domains found in Lgl, suggesting that these proteins may have closely related functions (Shimanski 2005)
    • HOMOLOGY
    interspecies homolog to drosophila Lgl
    Homologene
    FAMILY
  • WD repeat L(2)GL family
    • CATEGORY structural protein , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • control of cell proliferation
  • its expression increased cell adhesion and decreased cell migration (Shimanski 2005)
  • binds Myosin II and is involved in maintaining cell polarity and epithelial integrity (Shimanski 2005)
    • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of DLG1/SCRIB/LLGL1 tumour suppressor complex, interacting with tSNARE syntaxin 4 (Massimi 2008)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • non muscle myosin II heavy chain binding
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    in Smith-Magenis syndrome
    constitutional somatic mutation      
    mutated by aberrant splicing exclusively in hepatocellular carcinoma (HCC), and involved in HCC progression (Lu 2009)
    tumoral     --low  
    involved in development and progression of colon cancer and malignant melanoma (Tsuruga 2007)
    tumoral     --low  
    loss of expression in endometrial cancer may contribute to lymph node metastasis and it can be a factor of poor prognosis (Tsuruga 2007)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS